Carbonic Anhydrases Research Tools from BioVision

Carbonic anhydrases (CAs) are a class of commonly expressed metalloenzymes found in pancreatic cells, red blood cells, renal tubules and gastric mucosa. CAs help to catalyze the interconversion of carbonic acid and carbon dioxide.

These enzymes take part in various pathological and physiological processes such as lipogenesis, gluconeogenesis, tumorigenicity, ureagenesis, as well as the growth and virulence of different pathogens.

The U.S. FDA has approved a number of carbonic anhydrase inhibitors (CAIs) like ethoxzolamide, acetazolamide, dichlorophenamide, methazolamide, etc. as diuretic and anti-glaucoma agents. Recently, it has been identified that CAIs can be potentially used as novel anti-infective, anti-obesity and anti-cancer drugs.

In addition, recent research works indicate that CA activation may offer an innovative therapy for Alzheimer’s disease. BioVision provides CAIs and various products related to carbonic anhydrases—such as assay kits, enzymes and antibodies—for research purposes.

Table 1. Assay kits. Source: BioVision Incorporated

Product Name Cat. No. Size
Carbonic Anhydrase (CA) Activity Assay Kit (C) K472 100 assays
Carbonic Anhydrase (CA) Inhibitor Screening Kit (C) K473 100 assays
Carbonic anhydrase 9 (CA9)(Human) ELISA Kit E4353 100 assays

 

Table 2. Antibodies. Source: BioVision Incorporated

Product Name Cat. No. Size
Anti-CA12 Antibody A1865 100 µl
Anti-CA13 Antibody A1404 100 µl
Anti-Carbonic Anhydrase 2 Antibody A2007 100 µl
Anti-Carbonic Anhydrase IX Antibody (CA9/781) A1463 100 µg
Anti-CHST9 Antibody A1177 100 µl

 

Table 3. Proteins/enzymes. Source: BioVision Incorporated

Product Name Cat. No. Size
E. coli Recombinant Carbonic anhydrase P1049 10 µg, 50 µg
Human CellExp™ Carbonic Anhydrase 10/CA10, human recombinant 7485 10 µg
Human Recombinant Carbonic anhydrase 2 6390 100 µg
Human CellExp™ Carbonic Anhydrase 2/CA2, human recombinant 7479 10 µg, 50 µg
Carbonic Anhydrase 3, human recombinant 7833 10 µg, 50 µg
Human CellExp™ Carbonic Anhydrase 4/CA4, human recombinant 7484 10 µg
Human CellExp™ Carbonic Anhydrase 9/CA9, human recombinant 7478 10 µg
Human CellExp™ Carbonic Anhydrase IX / CA9, Human Recombinant P1336 10 µg
Carbonic Anhydrase XIV/CA14, Human Recombinant P1582 20 µg, 100 µg
Carbonic anhydrase-1, human recombinant P1048 10 µg, 50 µg
Carbonic anhydrase-8, human recombinant P1047 10 µg, 50 µg
Active Recombinant Human CAXII Protein P1704 20 µg, 50 µg
Recombinant E. coli, D-lactate Dehydrogenase P1053 10 µg, 50 µg

 

Table 4. Inhibitors. Source: BioVision Incorporated

Product Name Cat. No. Size Cas. No
Acetazolamide B3271 1 g, 5 g 59-66-5
Dichlorphenamide B3272 10 mg, 50 mg 120-97-8
Dorzolamide Hydrochloride B2185 10 mg, 50 mg 130693-82-2
Indisulam B2463 5 mg, 25 mg 165668-41-7
KC7F2 9641 10 mg, 50 mg 927822-86-4
Methazolamide B3259 10 mg, 50 mg 554-57-4
U-104 9631 5 mg, 25 mg 178606-66-1